Can we be Epigenetically proactive?1 Introduction2 The social individualist2.1 An egocentric evaluator2.2 Selective sympathy & empathetic xenophobia3 Neuronal epigenesis3.1 Genotype & brain phenotype: The paradox of non-linear evolution between genome & brain complexity3.2 The epigenesis of neuronal networks by selective stabilization of synapses3.3 The selection of cultural circuits in the brain during development & the epigenetic transmission of cultural imprints4 “Epigenetic rules” and top-down control of decision-making4.1 The hierarchical architecture of the brain4.2 A cascade model of top-down cognitive control 5 A naturalistic responsibility5.1 Proactive epigenesis5.2 Conclusion: A naturalistic responsibility